2JYI

Solution structure of MLL CXXC domain

2JYI の概要

• エントリーDOI: 10.2210/pdb2jyi/pdb
• 関連するPDBエントリー: 2j2s
• 分子名称: Zinc finger protein HRX, ZINC ION (2 entities in total)
• 機能のキーワード: protein, cxxc domain, mll, alternative splicing, bromodomain, chromosomal rearrangement, dna-binding, metal-binding, nucleus, phosphoprotein, polymorphism, proto-oncogene, transcription, transcription regulation, ubl conjugation, zinc, zinc-finger
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus. MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 6664.68

構造登録者

Cierpicki, T.,Bushweller, J.H. (登録日: 2007-12-13, 公開日: 2008-12-09, 最終更新日: 2024-05-29)

• 主引用文献: Cierpicki, T.,Riesbeck, L.E.,Grembecka, J.,Lukasik, S.M.,Omonkowska, M.,Shultis, D.,Zeleznik-Le, N.J.,Bushweller, J.H.; Structural basis for maintenance of unmethylated CpG elements by the CXXC domain of MLL and its critical contributions to MLL-AF9 immortalization activity; To be Published,

実験手法

SOLUTION NMR