2JT2

Solution Structure of the Aquifex aeolicus LpxC- CHIR-090 complex

Summary for 2JT2

Entry DOI	10.2210/pdb2jt2/pdb
Descriptor	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, N-{(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide (3 entities in total)
Functional Keywords	antibiotic, lipid a, hydroxamate, chir-090, hydrolase, lipid a biosynthesis, lipid synthesis
Biological source	Aquifex aeolicus
Total number of polymer chains	1
Total formula weight	31817.76
Authors	Barb, A.W.,Jiang, L.,Raetz, C.R.H.,Zhou, P. (deposition date: 2007-07-18, release date: 2007-12-04, Last modification date: 2021-10-20)
Primary citation	Barb, A.W.,Jiang, L.,Raetz, C.R.,Zhou, P. Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding Proc.Natl.Acad.Sci.Usa, 104:18433-18438, 2007 Cited by PubMed: 18025458 DOI: 10.1073/pnas.0709412104 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation