2JT2

Solution Structure of the Aquifex aeolicus LpxC- CHIR-090 complex

2JT2 の概要

• エントリーDOI: 10.2210/pdb2jt2/pdb
• 分子名称: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, N-{(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide (3 entities in total)
• 機能のキーワード: antibiotic, lipid a, hydroxamate, chir-090, hydrolase, lipid a biosynthesis, lipid synthesis
• 由来する生物種: Aquifex aeolicus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31817.76

構造登録者

Barb, A.W.,Jiang, L.,Raetz, C.R.H.,Zhou, P. (登録日: 2007-07-18, 公開日: 2007-12-04, 最終更新日: 2024-05-29)

• 主引用文献: Barb, A.W.,Jiang, L.,Raetz, C.R.,Zhou, P.; Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding; Proc.Natl.Acad.Sci.Usa, 104:18433-18438, 2007; PubMed: 18025458; DOI: 10.1073/pnas.0709412104

実験手法

SOLUTION NMR