2JKF

Plasmodium falciparum profilin

2JKF の概要

• エントリーDOI: 10.2210/pdb2jkf/pdb
• 関連するPDBエントリー: 2JKG
• 分子名称: PROFILIN (2 entities in total)
• 機能のキーワード: proline-rich ligand, plasmodium falciparum, malaria, profilin, cytoskeleton, actin filament structural protein, protein-binding, protein binding
• 由来する生物種: PLASMODIUM FALCIPARUM
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20102.01

構造登録者

Kursula, I.,Kursula, P.,Ganter, M.,Panjikar, S.,Matuschewski, K.,Schueler, H. (登録日: 2008-08-28, 公開日: 2008-09-23, 最終更新日: 2024-05-08)

主引用文献

Kursula, I.,Kursula, P.,Ganter, M.,Panjikar, S.,Matuschewski, K.,Schueler, H.
Structural Basis for Parasite-Specific Functions of the Divergent Profilin of Plasmodium Falciparum
Structure, 16:1638-, 2008

PubMed Abstract: Profilins are key regulators of actin dynamics. They sequester actin monomers, forming a pool for rapid polymer formation stimulated by proteins such as formins. Apicomplexan parasites utilize a highly specialized microfilament system for motility and host cell invasion. Their genomes encode only a small number of divergent actin regulators. We present the first crystal structure of an apicomplexan profilin, that of the malaria parasite Plasmodium falciparum, alone and in complex with a polyproline ligand peptide. The most striking feature of Plasmodium profilin is a unique minidomain consisting of a large beta-hairpin extension common to all apicomplexan parasites, and an acidic loop specific for Plasmodium species. Reverse genetics in the rodent malaria model, Plasmodium berghei, suggests that profilin is essential for the invasive blood stages of the parasite. Together, our data establish the structural basis for understanding the functions of profilin in the malaria parasite.

PubMed: 19000816
DOI: 10.1016/J.STR.2008.09.008

実験手法

X-RAY DIFFRACTION (2.31 Å)