2JJA
Crystal structure of GNA with synthetic copper base pair
Summary for 2JJA
| Entry DOI | 10.2210/pdb2jja/pdb |
| Descriptor | GNA, COPPER (II) ION, MAGNESIUM ION, ... (6 entities in total) |
| Functional Keywords | nucleic acid, synthetic base pair, glycol nucleic acid, gna, rna |
| Biological source | SYNTHETIC CONSTRUCT |
| Total number of polymer chains | 1 |
| Total formula weight | 2536.71 |
| Authors | Schlegel, M.K.,Essen, L.-O.,Meggers, E. (deposition date: 2008-03-28, release date: 2008-07-22, Last modification date: 2024-06-19) |
| Primary citation | Schlegel, M.K.,Essen, L.-O.,Meggers, E. Duplex Structure of a Minimal Nucleic Acid. J.Am.Chem.Soc., 130:8158-, 2008 Cited by PubMed Abstract: The crystal structure of an 8-mer (S)-GNA duplex is presented. As a tool for phasing, the anomalous diffraction of two copper(II) ions within two artificial metallo-base pairs was employed. The duplex structure confirms a canonical Watson-Crick base pairing scheme of GNA with antiparallel strands. The duplex secondary structure is distinct from canonical A- and B-form nucleic acids and can be described as a right-handed helical ribbon wrapped around the helix axis, resulting in a large hollow core. Most intriguingly, neighboring base pairs slide strongly against each other, resulting in extensive interstrand base-base hydrophobic interactions along with unusual hydrophobic intrastrand interactions of nucleobases with their backbone. These results reveal how a minimal nucleic acid backbone can support highly stable Watson-Crick-like duplex formation. PubMed: 18529005DOI: 10.1021/JA802788G PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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