2JHC

The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping production-line

Summary for 2JHC

Entry DOI	10.2210/pdb2jhc/pdb
Related	2JH9 2JHA 2JHP
Descriptor	VP4 CORE PROTEIN, GUANINE (2 entities in total)
Functional Keywords	guanylyltransferase, viral capping enzyme, core protein, virion protein, methyltransferase, viral protein
Biological source	BLUETONGUE VIRUS 10 (ISOLATE USA)
Cellular location	Virion : P07132
Total number of polymer chains	1
Total formula weight	75803.96
Authors	Sutton, G.,Grimes, J.M.,Stuart, D.I.,Roy, P. (deposition date: 2007-02-21, release date: 2007-04-10, Last modification date: 2024-05-08)
Primary citation	Sutton, G.,Grimes, J.M.,Stuart, D.I.,Roy, P. Bluetongue Virus Vp4 is an RNA-Capping Assembly Line. Nat.Struct.Mol.Biol., 14:449-, 2007 Cited by PubMed Abstract: Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure. PubMed: 17417654 DOI: 10.1038/NSMB1225 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation