2JFH

Crystal structure of MurD ligase in complex with L-Glu containing sulfonamide inhibitor

2JFH の概要

• エントリーDOI: 10.2210/pdb2jfh/pdb
• 関連するPDBエントリー: 1E0D 1EEH 1UAG 2JFF 2JFG 2UAG 3UAG 4UAG
• 分子名称: UDP-N-ACETYLMURAMOYL-ALANINE-D-GLUTAMATE LIGASE, N-[(6-BUTOXYNAPHTHALEN-2-YL)SULFONYL]-L-GLUTAMIC ACID, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: murd-inhibitor complex, peptidoglycan synthesis, ligase, cell wall, cell shape, cell cycle, nucleotide-binding, sulfonamide inhibitor, murd ligase, atp-binding, cell division
• 由来する生物種: ESCHERICHIA COLI
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48484.91

構造登録者

Kotnik, M.,Humljan, J.,Contreras-Martel, C.,Oblak, M.,Kristan, K.,Herve, M.,Blanot, D.,Urleb, U.,Gobec, S.,Dessen, A.,Solmajer, T. (登録日: 2007-02-01, 公開日: 2007-05-15, 最終更新日: 2023-12-13)

• 主引用文献: Kotnik, M.,Humljan, J.,Contreras-Martel, C.,Oblak, M.,Kristan, K.,Herve, M.,Blanot, D.,Urleb, U.,Gobec, S.,Dessen, A.,Solmajer, T.; Structural and Functional Characterization of Enantiomeric Glutamic Acid Derivatives as Potential Transition State Analogue Inhibitors of Murd Ligase.; J.Mol.Biol., 370:107-, 2007; PubMed: 17507028; DOI: 10.1016/J.JMB.2007.04.048

実験手法

X-RAY DIFFRACTION (1.97 Å)