2JF1

CRYSTAL STRUCTURE OF THE FILAMIN A REPEAT 21 COMPLEXED WITH THE INTEGRIN BETA2 CYTOPLASMIC TAIL PEPTIDE

Summary for 2JF1

• Entry DOI: 10.2210/pdb2jf1/pdb
• Related: 1JX3 1L3Y 1YUK
• Descriptor: FILAMIN-A, INTEGRIN BETA-2 SUBUNIT, GLYCEROL, ... (4 entities in total)
• Functional Keywords: actin-binding, cell adhesion, transmembrane, acetylation, polymorphism, cytoskeleton, glycoprotein, filamin, complex, membrane, integrin, receptor, pyrrolidone carboxylic acid, phosphorylation, disease mutation, immunoglobulin like
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm, cell cortex: P21333; Membrane; Single-pass type I membrane protein: P05107
• Total number of polymer chains: 2
• Total formula weight: 14270.84

Authors

Kiema, T.,Ylanne, J. (deposition date: 2007-01-25, release date: 2008-02-05, Last modification date: 2023-12-13)

• Primary citation: Takala, H.,Nurminen, E.,Nurmi, S.M.,Aatonen, M.,Strandin, T.,Takatalo, M.,Kiema, T.,Gahmberg, C.G.,Ylanne, J.,Fagerholm, S.C.; Beta2 Integrin Phosphorylation on Thr758 Acts as a Molecular Switch to Regulate 14-3-3 and Filamin Binding.; Blood, 112:1853-, 2008; PubMed: 18550856; DOI: 10.1182/BLOOD-2007-12-127795

Experimental method

X-RAY DIFFRACTION (2.2 Å)