2JEW

Crystal structure of ((2S)-5-amino-2-((1-n-propyl-1H-imidazol-4-yl) methyl)pentanoic acid) UK396,082 a TAFIa inhibitor, Bound to Activated Porcine Pancreatic carboxypeptidaseB

Summary for 2JEW

Entry DOI	10.2210/pdb2jew/pdb
Related	1NSA 1PBA 1Z5R 1ZG7 1ZG8 1ZG9
Descriptor	CARBOXYPEPTIDASE B, ZINC ION, (2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]PENTANOIC ACID, ... (4 entities in total)
Functional Keywords	carboxypeptidase, carboxypeptidase b, direct metal-binding, metalloprotease, protease, hydrolase, zinc, zymogen, exopeptidase
Biological source	SUS SCROFA (PIG)
Cellular location	Secreted : P09955
Total number of polymer chains	1
Total formula weight	35109.99
Authors	Brown, D.G.,Moore, R.S. (deposition date: 2007-01-24, release date: 2007-11-20, Last modification date: 2023-12-13)
Primary citation	Bunnage, M.E.,Blagg, J.,Steele, J.,Owen, D.R.,Allerton, C.,McElroy, A.B.,Miller, D.,Ringer, T.,Butcher, K.,Beaumont, K.,Evans, K.,Gray, A.J.,Holland, S.J.,Feeder, N.,Moore, R.S.,Brown, D.G. Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis. J. Med. Chem., 50:6095-6103, 2007 Cited by PubMed: 17990866 DOI: 10.1021/jm0702433 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation