2JEW

Crystal structure of ((2S)-5-amino-2-((1-n-propyl-1H-imidazol-4-yl) methyl)pentanoic acid) UK396,082 a TAFIa inhibitor, Bound to Activated Porcine Pancreatic carboxypeptidaseB

2JEW の概要

• エントリーDOI: 10.2210/pdb2jew/pdb
• 関連するPDBエントリー: 1NSA 1PBA 1Z5R 1ZG7 1ZG8 1ZG9
• 分子名称: CARBOXYPEPTIDASE B, ZINC ION, (2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]PENTANOIC ACID, ... (4 entities in total)
• 機能のキーワード: carboxypeptidase, carboxypeptidase b, direct metal-binding, metalloprotease, protease, hydrolase, zinc, zymogen, exopeptidase
• 由来する生物種: SUS SCROFA (PIG)
• 細胞内の位置: Secreted : P09955
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35109.99

構造登録者

Brown, D.G.,Moore, R.S. (登録日: 2007-01-24, 公開日: 2007-11-20, 最終更新日: 2023-12-13)

• 主引用文献: Bunnage, M.E.,Blagg, J.,Steele, J.,Owen, D.R.,Allerton, C.,McElroy, A.B.,Miller, D.,Ringer, T.,Butcher, K.,Beaumont, K.,Evans, K.,Gray, A.J.,Holland, S.J.,Feeder, N.,Moore, R.S.,Brown, D.G.; Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis.; J. Med. Chem., 50:6095-6103, 2007; PubMed: 17990866; DOI: 10.1021/jm0702433

実験手法

X-RAY DIFFRACTION (1.4 Å)