2JE5

STRUCTURAL AND MECHANISTIC BASIS OF PENICILLIN BINDING PROTEIN INHIBITION BY LACTIVICINS

Summary for 2JE5

• Entry DOI: 10.2210/pdb2je5/pdb
• Related: 2BG1 2BG3 2BG4 2FFF 2JCH 2JCI
• Descriptor: PENICILLIN-BINDING PROTEIN 1B, (2E)-2-{[(2S)-2-(ACETYLAMINO)-2-CARBOXYETHOXY]IMINO}PENTANEDIOIC ACID, SULFATE ION, ... (5 entities in total)
• Functional Keywords: peptidoglycan synthesis multifunctional enzyme, cell wall, peptidoglycan, gamma lactam antibiotics, drug-binding protein
• Biological source: STREPTOCOCCUS PNEUMONIAE
• Total number of polymer chains: 2
• Total formula weight: 157771.05

Authors

Macheboeuf, P.,Fisher, D.S.,Brown, T.J.,Zervosen, A.,Luxen, A.,Joris, B.,Dessen, A.,Schofield, C.J. (deposition date: 2007-01-15, release date: 2007-08-14, Last modification date: 2023-12-13)

• Primary citation: Macheboeuf, P.,Fisher, D.S.,Brown, T.J.,Zervosen, A.,Luxen, A.,Joris, B.,Dessen, A.,Schofield, C.J.; Structural and Mechanistic Basis of Penicillin-Binding Protein Inhibition by Lactivicins; Nat.Chem.Biol., 3:565-, 2007; PubMed: 17676039; DOI: 10.1038/NCHEMBIO.2007.21

Experimental method

X-RAY DIFFRACTION (2.6 Å)