2JE0

Crystal Structure of pp32

Summary for 2JE0

Entry DOI	10.2210/pdb2je0/pdb
Related	2JE1
Descriptor	ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A, GLYCEROL (3 entities in total)
Functional Keywords	nuclear protein
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus: P39687
Total number of polymer chains	6
Total formula weight	102895.28
Authors	Huyton, T.,Wolberger, C. (deposition date: 2007-01-12, release date: 2007-06-26, Last modification date: 2024-05-01)
Primary citation	Huyton, T.,Wolberger, C. The Crystal Structure of the Tumor Suppressor Protein Pp32 (Anp32A): Structural Insights Into Anp32 Family of Proteins. Protein Sci., 16:1308-, 2007 Cited by PubMed Abstract: The tumor suppressor protein pp32 is highly overexpressed in many cancers of the breast and prostate, and has also been implicated in the neurodegenerative disease spinocerebellar ataxias type 1 (SCA1). Pp32 is a multifunctional protein that is involved in the regulation of transcription, apoptosis, phosphorylation, and cell cycle progression, the latter through its association with the hyperphosphorylated form of the retinoblastoma tumor suppressor. We have determined the structure of an N-terminal pp32 fragment comprising a capped leucine-rich repeat (LRR) domain, which provides insight into the structural and biochemical properties of the pp32 (Anp32) family of proteins. PubMed: 17567741 DOI: 10.1110/PS.072803507 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation