2JE0

Crystal Structure of pp32

2JE0 の概要

• エントリーDOI: 10.2210/pdb2je0/pdb
• 関連するPDBエントリー: 2JE1
• 分子名称: ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A, GLYCEROL (3 entities in total)
• 機能のキーワード: nuclear protein
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus: P39687
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 102895.28

構造登録者

Huyton, T.,Wolberger, C. (登録日: 2007-01-12, 公開日: 2007-06-26, 最終更新日: 2024-05-01)

主引用文献

Huyton, T.,Wolberger, C.
The Crystal Structure of the Tumor Suppressor Protein Pp32 (Anp32A): Structural Insights Into Anp32 Family of Proteins.
Protein Sci., 16:1308-, 2007

PubMed Abstract: The tumor suppressor protein pp32 is highly overexpressed in many cancers of the breast and prostate, and has also been implicated in the neurodegenerative disease spinocerebellar ataxias type 1 (SCA1). Pp32 is a multifunctional protein that is involved in the regulation of transcription, apoptosis, phosphorylation, and cell cycle progression, the latter through its association with the hyperphosphorylated form of the retinoblastoma tumor suppressor. We have determined the structure of an N-terminal pp32 fragment comprising a capped leucine-rich repeat (LRR) domain, which provides insight into the structural and biochemical properties of the pp32 (Anp32) family of proteins.

PubMed: 17567741
DOI: 10.1110/PS.072803507

実験手法

X-RAY DIFFRACTION (2.4 Å)