2JC1

CRYSTAL STRUCTURE OF HEPATITIS C VIRUS POLYMERASE IN COMPLEX WITH INHIBITOR SB698223

2JC1 の概要

関連するPDBエントリー2I1R 2JC0
分子名称RNA-DEPENDENT RNA-POLYMERASE, (2S,4S,5R)-1-(4-TERT-BUTYLBENZOYL)-2-ISOBUTYL-5-(1,3-THIAZOL-2-YL)PYRROLIDINE-2,4-DICARBOXYLIC ACID (3 entities in total)
機能のキーワードhepatitis, polymerase, hydrolase
由来する生物種HEPATITIS C VIRUS
ポリマー鎖数2
分子量合計127582.45
構造登録者
Wonacott, A.,Skarzynski, T.,Singh, O.M. (登録日: 2006-12-18, 公開日: 2007-02-13, 最終更新日: 2011-07-13)
主引用文献
Slater, M.J.,Amphlett, E.M.,Andrews, D.M.,Bravi, G.,Burton, G.,Cheasty, A.G.,Corfield, J.A.,Ellis, M.R.,Fenwick, R.H.,Fernandes, S.,Guidetti, R.,Haigh, D.,Hartley, C.D.,Howes, P.D.,Jackson, D.L.,Jarvest, R.L.,Lovegrove, V.L.,Medhurst, K.J.,Parry, N.R.,Price, H.,Shah, P.,Singh, O.M.,Stocker, R.,Thommes, P.,Wilkinson, C.,Wonacott, A.
Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate.
J.Med.Chem., 50:897-, 2007
PubMed: 17269759 (主引用文献が同じPDBエントリー)
DOI: 10.1021/JM061207R
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers501.6%3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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