2JBX

Crystal Structure of the myxoma virus anti-apoptotic protein M11L

2JBX の概要

• エントリーDOI: 10.2210/pdb2jbx/pdb
• 関連するPDBエントリー: 2JBY
• 分子名称: M11L PROTEIN (2 entities in total)
• 機能のキーワード: apoptosis, bcl-2 family, myxoma virus
• 由来する生物種: MYXOMA VIRUS
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33762.66

構造登録者

Kvansakul, M.,Van Delft, M.F.,Lee, E.F.,Gulbis, J.M.,Fairlie, W.D.,Huang, D.C.S.,Colman, P.M. (登録日: 2006-12-14, 公開日: 2007-03-27, 最終更新日: 2024-11-20)

主引用文献

Kvansakul, M.,Van Delft, M.F.,Lee, E.F.,Gulbis, J.M.,Fairlie, W.D.,Huang, D.C.S.,Colman, P.M.
A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak.
Mol.Cell, 25:933-, 2007

PubMed Abstract: Many viruses express antiapoptotic proteins to counter host defense mechanisms that would otherwise trigger the rapid clearance of infected cells. For example, adenoviruses and some gamma-herpesviruses express homologs of prosurvival Bcl-2 to subvert the host's apoptotic machinery. Myxoma virus, a double-stranded DNA virus of the pox family, harbors antiapoptotic M11L, its virulence factor. Analysis of its three-dimensional structure reveals that despite lacking any primary sequence similarity to Bcl-2, it adopts a virtually identical protein fold. This allows it to associate with BH3 domains, especially those of Bax and Bak. We found that M11L acts primarily by sequestering Bax and Bak, thereby blocking the killing action of these essential cell-death mediators. These findings expand the family of protein sequences that act like Bcl-2 to block apoptosis and support the conclusion that the prosurvival action of these proteins critically depends on their ability to bind and antagonize Bax and/or Bak.

PubMed: 17386268
DOI: 10.1016/J.MOLCEL.2007.02.004

実験手法

X-RAY DIFFRACTION (2.73 Å)