2JAH

Biochemical and structural analysis of the Clavulanic acid dehydeogenase (CAD) from Streptomyces clavuligerus

2JAH の概要

• エントリーDOI: 10.2210/pdb2jah/pdb
• 分子名称: CLAVULANIC ACID DEHYDROGENASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
• 機能のキーワード: short-chain dehydrogenase/reductase, lactamase inhibitor, antibiotic biosynthesis, nadph, oxidoreductase, clavulanic acid
• 由来する生物種: STREPTOMYCES CLAVULIGERUS
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 109723.12

構造登録者

MacKenzie, A.K.,Kershaw, N.J.,Hernandez, H.,Robinson, C.V.,Schofield, C.J.,Andersson, I. (登録日: 2006-11-28, 公開日: 2007-02-20, 最終更新日: 2011-07-13)

• 主引用文献: Mackenzie, A.K.,Kershaw, N.J.,Hernandez, H.,Robinson, C.V.,Schofield, C.J.,Andersson, I.; Clavulanic Acid Dehydrogenase: Structural and Biochemical Analysis of the Final Step in the Biosynthesis of the Beta-Lactamase Inhibitor Clavulanic Acid; Biochemistry, 46:1523-, 2007; PubMed: 17279617; DOI: 10.1021/BI061978X

実験手法

X-RAY DIFFRACTION (1.8 Å)