2J9A
blLAP in Complex with Microginin FR1
Summary for 2J9A
Entry DOI | 10.2210/pdb2j9a/pdb |
Related | 1BLL 1BPM 1BPN 1LAM 1LAN 1LAP 1LCP 2EWB |
Related PRD ID | PRD_000705 |
Descriptor | CYTOSOL AMINOPEPTIDASE, MICROGININ FR1, CHLORIDE ION, ... (8 entities in total) |
Functional Keywords | hydrolase, leucine aminopeptidase, acetylation, aminopeptidase, microginin, microcystins, hydrolase-inhibitor complex metal-binding, protease, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | BOS TAURUS (BOVINE) More |
Total number of polymer chains | 2 |
Total formula weight | 54379.09 |
Authors | Kraft, M.,Schleberger, C.,Weckesser, J.,Schulz, G.E. (deposition date: 2006-11-06, release date: 2006-12-06, Last modification date: 2024-11-06) |
Primary citation | Kraft, M.,Schleberger, C.,Weckesser, J.,Schulz, G.E. Binding Structure of the Leucine Aminopeptidase Inhibitor Microginin Fr1. FEBS Lett., 580:6943-, 2006 Cited by PubMed Abstract: Natural bioactive compounds are of general interest for pharmaceutical research because they may serve as leads in drug development campaigns. Among them, microginins are linear peptides known to inhibit various exopeptidases. The crystal structure of microginin FR1 from Microcystis sp. bound to bovine lens leucine aminopeptidase was established at 1.73 Angstrom resolution. The observed binding structure could be beneficial for the design of potent aminopeptidase inhibitors. PubMed: 17157838DOI: 10.1016/J.FEBSLET.2006.11.060 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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