2J9A

blLAP in Complex with Microginin FR1

Summary for 2J9A

Entry DOI	10.2210/pdb2j9a/pdb
Related	1BLL 1BPM 1BPN 1LAM 1LAN 1LAP 1LCP 2EWB
Related PRD ID	PRD_000705
Descriptor	CYTOSOL AMINOPEPTIDASE, MICROGININ FR1, CHLORIDE ION, ... (8 entities in total)
Functional Keywords	hydrolase, leucine aminopeptidase, acetylation, aminopeptidase, microginin, microcystins, hydrolase-inhibitor complex metal-binding, protease, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	BOS TAURUS (BOVINE) More
Total number of polymer chains	2
Total formula weight	54379.09
Authors	Kraft, M.,Schleberger, C.,Weckesser, J.,Schulz, G.E. (deposition date: 2006-11-06, release date: 2006-12-06, Last modification date: 2024-11-06)
Primary citation	Kraft, M.,Schleberger, C.,Weckesser, J.,Schulz, G.E. Binding Structure of the Leucine Aminopeptidase Inhibitor Microginin Fr1. FEBS Lett., 580:6943-, 2006 Cited by PubMed Abstract: Natural bioactive compounds are of general interest for pharmaceutical research because they may serve as leads in drug development campaigns. Among them, microginins are linear peptides known to inhibit various exopeptidases. The crystal structure of microginin FR1 from Microcystis sp. bound to bovine lens leucine aminopeptidase was established at 1.73 Angstrom resolution. The observed binding structure could be beneficial for the design of potent aminopeptidase inhibitors. PubMed: 17157838 DOI: 10.1016/J.FEBSLET.2006.11.060 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.73 Å)

Structure validation