2J9A

blLAP in Complex with Microginin FR1

2J9A の概要

• エントリーDOI: 10.2210/pdb2j9a/pdb
• 関連するPDBエントリー: 1BLL 1BPM 1BPN 1LAM 1LAN 1LAP 1LCP 2EWB
• 関連するBIRD辞書のPRD_ID: PRD_000705
• 分子名称: CYTOSOL AMINOPEPTIDASE, MICROGININ FR1, CHLORIDE ION, ... (8 entities in total)
• 機能のキーワード: hydrolase, leucine aminopeptidase, acetylation, aminopeptidase, microginin, microcystins, hydrolase-inhibitor complex metal-binding, protease, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: BOS TAURUS (BOVINE); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54379.09

構造登録者

Kraft, M.,Schleberger, C.,Weckesser, J.,Schulz, G.E. (登録日: 2006-11-06, 公開日: 2006-12-06, 最終更新日: 2024-11-06)

主引用文献

Kraft, M.,Schleberger, C.,Weckesser, J.,Schulz, G.E.
Binding Structure of the Leucine Aminopeptidase Inhibitor Microginin Fr1.
FEBS Lett., 580:6943-, 2006

PubMed Abstract: Natural bioactive compounds are of general interest for pharmaceutical research because they may serve as leads in drug development campaigns. Among them, microginins are linear peptides known to inhibit various exopeptidases. The crystal structure of microginin FR1 from Microcystis sp. bound to bovine lens leucine aminopeptidase was established at 1.73 Angstrom resolution. The observed binding structure could be beneficial for the design of potent aminopeptidase inhibitors.

PubMed: 17157838
DOI: 10.1016/J.FEBSLET.2006.11.060

実験手法

X-RAY DIFFRACTION (1.73 Å)