2J90
Crystal structure of human ZIP kinase in complex with a tetracyclic pyridone inhibitor (Pyridone 6)
Summary for 2J90
Entry DOI | 10.2210/pdb2j90/pdb |
Related | 1YRP |
Descriptor | DEATH-ASSOCIATED PROTEIN KINASE 3, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | nuclear protein, nucleotide-binding, serine/threonine- protein kinase, chromatin regulator, myosin phosphorylation, kinase, muscle, apoptosis, transferase, atp-binding |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: O43293 |
Total number of polymer chains | 2 |
Total formula weight | 71324.24 |
Authors | Turnbull, A.P.,Berridge, G.,Fedorov, O.,Pike, A.C.W.,Savitsky, P.,Eswaran, J.,Papagrigoriou, E.,Ugochukwa, E.,von Delft, F.,Gileadi, O.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Sundstrom, M.,Knapp, S. (deposition date: 2006-10-31, release date: 2006-11-07, Last modification date: 2023-12-13) |
Primary citation | Pike, A.C.W.,Rellos, P.,Niesen, F.H.,Turnbull, A.,Oliver, A.W.,Parker, S.A.,Turk, B.E.,Pearl, L.H.,Knapp, S. Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites. Embo J., 27:704-, 2008 Cited by PubMed: 18239682DOI: 10.1038/EMBOJ.2008.8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report