2J51

Crystal structure of Human STE20-like kinase bound to 5-Amino-3-((4-(aminosulfonyl)phenyl)amino) -N-(2,6-difluorophenyl)-1H-1,2,4-triazole- 1-carbothioamide

2J51 の概要

• エントリーDOI: 10.2210/pdb2j51/pdb
• 分子名称: STE20-LIKE SERINE/THREONINE-PROTEIN KINASE, 1,2-ETHANEDIOL, THIOCYANATE ION, ... (5 entities in total)
• 機能のキーワード: transferase, serine/threonine-protein kinase, atp-binding, phosphorylation, muscle development, kinase, apoptosis, germinal centre kinase, serine/threonine kinase 2, nucleotide-binding
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm (By similarity): Q9H2G2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37893.86

構造登録者

Pike, A.C.W.,Rellos, P.,Fedorov, O.,Keates, T.,Salah, E.,Savitsky, P.,Papagrigoriou, E.,Turnbull, A.P.,Debreczeni, J.E.,von Delft, F.,Arrowsmith, C.,Edwards, A.,Weigelt, J.,Sundstrom, M.,Knapp, S. (登録日: 2006-09-08, 公開日: 2006-10-03, 最終更新日: 2023-12-13)

• 主引用文献: Pike, A.C.W.,Rellos, P.,Niesen, F.H.,Turnbull, A.,Oliver, A.W.,Parker, S.A.,Turk, B.E.,Pearl, L.H.,Knapp, S.; Activation Segment Dimerization: A Mechanism for Kinase Autophosphorylation of Non-Consensus Sites.; Embo J., 27:704-, 2008; PubMed: 18239682; DOI: 10.1038/EMBOJ.2008.8

実験手法

X-RAY DIFFRACTION (2.1 Å)