2J47

Bacteroides thetaiotaomicron GH84 O-GlcNAcase in complex with a imidazole-pugnac hybrid inhibitor

2J47 の概要

• エントリーDOI: 10.2210/pdb2j47/pdb
• 関連するPDBエントリー: 2CHN 2CHO
• 分子名称: GLUCOSAMINIDASE, (5R,6R,7R,8S)-8-(ACETYLAMINO)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-N-PHENYL-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXAMIDE, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: inhibitor, o-glcnacase, imidazole, gh84, pugnac, enzyme, inhibition
• 由来する生物種: BACTEROIDES THETAIOTAOMICRON
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 82769.57

構造登録者

Dennis, R.J.,Davies, G.J. (登録日: 2006-08-25, 公開日: 2006-10-03, 最終更新日: 2023-12-13)

主引用文献

Shanmugasundaram, B.,Debowski, A.W.,Dennis, R.J.,Davies, G.J.,Vocadlo, D.J.,Vasella, A.
Inhibition of O-Glcnacase by a Gluco-Configured Nagstatin and a Pugnac-Imidazole Hybrid Inhibitor
Chem. Commun., 42:4372-, 2006

PubMed Abstract: Synthesis of a PUGNAc-imidazole hybrid and its characterization as an inhibitor of human O-GlcNAcase through enzyme kinetics and X-ray structural analysis.

PubMed: 17057847
DOI: 10.1039/B612154C

実験手法

X-RAY DIFFRACTION (1.98 Å)