2IYA

The crystal structure of macrolide glycosyltransferases: A blueprint for antibiotic engineering

Summary for 2IYA

• Entry DOI: 10.2210/pdb2iya/pdb
• Descriptor: OLEANDOMYCIN GLYCOSYLTRANSFERASE, URIDINE-5'-DIPHOSPHATE, (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-HYDROXY-5,7,8,11,13,15-HEXAMETHYL-4,10-DIOXO-14-{[3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSYL]OXY}-1,9-DIOXASPIRO[2.13]HEXADEC-12-YL 2,6-DIDEOXY-3-O-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSIDE, ... (4 entities in total)
• Functional Keywords: carbohydrate, glycosylation, glycosyltransferase, enzyme, macrolide, transferase
• Biological source: STREPTOMYCES ANTIBIOTICUS
• Total number of polymer chains: 2
• Total formula weight: 93609.76

Authors

Bolam, D.N.,Roberts, S.M.,Proctor, M.R.,Turkenburg, J.P.,Dodson, E.J.,Martinez-Fleites, C.,Yang, M.,Davis, B.G.,Davies, G.J.,Gilbert, H.J. (deposition date: 2006-07-13, release date: 2007-03-27, Last modification date: 2018-01-24)

• Primary citation: Bolam, D.N.,Roberts, S.M.,Proctor, M.R.,Turkenburg, J.P.,Dodson, E.J.,Martinez-Fleites, C.,Yang, M.,Davis, B.G.,Davies, G.J.,Gilbert, H.J.; The Crystal Structure of Two Macrolide Glycosyltransferases Provides a Blueprint for Host Cell Antibiotic Immunity.; Proc.Natl.Acad.Sci.USA, 104:5336-, 2007; PubMed: 17376874; DOI: 10.1073/PNAS.0607897104

Experimental method

X-RAY DIFFRACTION (1.7 Å)