2IWI

CRYSTAL STRUCTURE OF THE HUMAN PIM2 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1

2IWI の概要

• エントリーDOI: 10.2210/pdb2iwi/pdb
• 分子名称: SERINE/THREONINE-PROTEIN KINASE PIM-2, RUTHENIUM-PYRIDOCARBAZOLE-1 (2 entities in total)
• 機能のキーワード: nucleotide-binding, serine/threonine-protein kinase, pim2, kinase, cancer, leukemia, transferase, atp-binding, proto-oncogene, phosphorylation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69593.63

構造登録者

Russo, S.,Debreczeni, J.E.,Amos, A.,Bullock, A.N.,Fedorov, O.,Niesen, F.,Sobott, F.,Turnbull, A.,Pike, A.C.W.,Ugochukwu, E.,Papagrigoriou, E.,Bunkoczi, G.,Gorrec, F.,Edwards, A.,Arrowsmith, C.,Weigelt, J.,Sundstrom, M.,von Delft, F.,Knapp, S. (登録日: 2006-06-30, 公開日: 2006-08-02, 最終更新日: 2023-12-13)

主引用文献

Bullock, A.N.,Russo, S.,Amos, A.,Pagano, N.,Bregman, H.,Debreczeni, J.E.,Lee, W.H.,von Delft, F.,Meggers, E.,Knapp, S.
Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.
PLoS ONE, 4:e7112-e7112, 2009

PubMed Abstract: The serine/threonine kinase PIM2 is highly expressed in human leukemia and lymphomas and has been shown to positively regulate survival and proliferation of tumor cells. Its diverse ATP site makes PIM2 a promising target for the development of anticancer agents. To date our knowledge of catalytic domain structures of the PIM kinase family is limited to PIM1 which has been extensively studied and which shares about 50% sequence identity with PIM2.

PubMed: 19841674
DOI: 10.1371/journal.pone.0007112

実験手法

X-RAY DIFFRACTION (2.8 Å)