2IWI

CRYSTAL STRUCTURE OF THE HUMAN PIM2 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1

2IWI の概要

• エントリーDOI: 10.2210/pdb2iwi/pdb
• 分子名称: SERINE/THREONINE-PROTEIN KINASE PIM-2, RUTHENIUM-PYRIDOCARBAZOLE-1 (2 entities in total)
• 機能のキーワード: nucleotide-binding, serine/threonine-protein kinase, pim2, kinase, cancer, leukemia, transferase, atp-binding, proto-oncogene, phosphorylation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69593.63

構造登録者

Russo, S.,Debreczeni, J.E.,Amos, A.,Bullock, A.N.,Fedorov, O.,Niesen, F.,Sobott, F.,Turnbull, A.,Pike, A.C.W.,Ugochukwu, E.,Papagrigoriou, E.,Bunkoczi, G.,Gorrec, F.,Edwards, A.,Arrowsmith, C.,Weigelt, J.,Sundstrom, M.,von Delft, F.,Knapp, S. (登録日: 2006-06-30, 公開日: 2006-08-02, 最終更新日: 2023-12-13)

• 主引用文献: Bullock, A.N.,Russo, S.,Amos, A.,Pagano, N.,Bregman, H.,Debreczeni, J.E.,Lee, W.H.,von Delft, F.,Meggers, E.,Knapp, S.; Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.; PLoS ONE, 4:e7112-e7112, 2009; PubMed: 19841674; DOI: 10.1371/journal.pone.0007112

実験手法

X-RAY DIFFRACTION (2.8 Å)