2IUB

Crystal structure of a divalent metal ion transporter CorA at 2.9 A resolution.

Summary for 2IUB

• Entry DOI: 10.2210/pdb2iub/pdb
• Related: 2BBH 2BBJ
• Descriptor: DIVALENT CATION TRANSPORT-RELATED PROTEIN, CHLORIDE ION, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: membrane protein, cora, divalent cation, ion transporter
• Biological source: THERMOTOGA MARITIMA
• Cellular location: Cell inner membrane; Multi-pass membrane protein: Q9WZ31
• Total number of polymer chains: 10
• Total formula weight: 430355.61

Authors

Eshaghi, S.,Niegowski, D.,Kohl, A.,Martinez Molina, D.,Lesley, S.A.,Nordlund, P. (deposition date: 2006-06-01, release date: 2006-08-03, Last modification date: 2024-05-08)

Primary citation

Eshaghi, S.,Niegowski, D.,Kohl, A.,Martinez Molina, D.,Lesley, S.A.,Nordlund, P.
Crystal Structure of a Divalent Metal Ion Transporter Cora at 2.9 Angstrom Resolution.
Science, 313:354-, 2006

PubMed Abstract: CorA family members are ubiquitously distributed transporters of divalent metal cations and are considered to be the primary Mg2+ transporter of Bacteria and Archaea. We have determined a 2.9 angstrom resolution structure of CorA from Thermotoga maritima that reveals a pentameric cone-shaped protein. Two potential regulatory metal binding sites are found in the N-terminal domain that bind both Mg2+ and Co2+. The structure of CorA supports an efflux system involving dehydration and rehydration of divalent metal ions potentially mediated by a ring of conserved aspartate residues at the cytoplasmic entrance and a carbonyl funnel at the periplasmic side of the pore.

PubMed: 16857941
DOI: 10.1126/SCIENCE.1127121

Experimental method

X-RAY DIFFRACTION (2.9 Å)