2ITZ
Crystal structure of EGFR kinase domain L858R mutation in complex with Iressa
Summary for 2ITZ
Entry DOI | 10.2210/pdb2itz/pdb |
Related | 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY |
Descriptor | EPIDERMAL GROWTH FACTOR RECEPTOR, CHLORIDE ION, Gefitinib, ... (4 entities in total) |
Functional Keywords | receptor, cell cycle, atp-binding, transferase, transmembrane, phosphorylation, disease mutation, glycoprotein, anti-oncogene, nucleotide- binding, iressa, egfr, l858r, zd1839, membrane, tyrosine-protein kinase, epidermal growth factor |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 37830.52 |
Authors | Yun, C.-H.,Boggon, T.J.,Li, Y.,Woo, S.,Greulich, H.,Meyerson, M.,Eck, M.J. (deposition date: 2006-05-25, release date: 2007-04-03, Last modification date: 2024-03-27) |
Primary citation | Yun, C.-H.,Boggon, T.J.,Li, Y.,Woo, S.,Greulich, H.,Meyerson, M.,Eck, M.J. Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11:217-, 2007 Cited by PubMed: 17349580DOI: 10.1016/J.CCR.2006.12.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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