2IT4

X ray structure of the complex between Carbonic Anhydrase I and the phosphonate antiviral drug foscarnet

2IT4 の概要

• エントリーDOI: 10.2210/pdb2it4/pdb
• 分子名称: Carbonic anhydrase 1, ZINC ION, PHOSPHONOFORMIC ACID, ... (4 entities in total)
• 機能のキーワード: carbonic anhydrase, antiviral, crystal stucture, lyase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00915
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57066.08

構造登録者

Temperini, C.,Innocenti, A.,Guerri, A.,Scozzafava, A.,Supuran, C.T. (登録日: 2006-10-19, 公開日: 2007-09-11, 最終更新日: 2023-08-30)

• 主引用文献: Temperini, C.,Innocenti, A.,Guerri, A.,Scozzafava, A.,Rusconi, S.,Supuran, C.T.; Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.; Bioorg.Med.Chem.Lett., 17:2210-2215, 2007; PubMed: 17314045; DOI: 10.1016/j.bmcl.2007.01.113

実験手法

X-RAY DIFFRACTION (2 Å)