2ISE

Botulinum Neurotoxin A Light Chain WT Crystal Form A

Summary for 2ISE

• Entry DOI: 10.2210/pdb2ise/pdb
• Related: 2ISG 2ISH
• Descriptor: Neurotoxin BoNT/A, ZINC ION (3 entities in total)
• Functional Keywords: botulinum neurotoxin, toxin
• Biological source: Clostridium botulinum
• Total number of polymer chains: 2
• Total formula weight: 96457.49

Authors

Brunger, A.T.,Stegmann, C.M. (deposition date: 2006-10-17, release date: 2006-11-07, Last modification date: 2023-08-30)

• Primary citation: Burnett, J.C.,Ruthel, G.,Stegmann, C.M.,Panchal, R.G.,Nguyen, T.L.,Hermone, A.R.,Stafford, R.G.,Lane, D.J.,Kenny, T.A.,McGrath, C.F.,Wipf, P.,Stahl, A.M.,Schmidt, J.J.,Gussio, R.,Brunger, A.T.,Bavari, S.; Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.; J.Biol.Chem., 282:5004-5014, 2007; PubMed: 17092934; DOI: 10.1074/jbc.M608166200

Experimental method

X-RAY DIFFRACTION (2.2 Å)