2ISD

PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT

「1ISD」から置き換えられました

2ISD の概要

• エントリーDOI: 10.2210/pdb2isd/pdb
• 分子名称: PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C, ISOZYME DELTA1, ACETATE ION (3 entities in total)
• 機能のキーワード: phosphoric diester hydrolase, hydrolase, lipid degradation, transducer, calcium-binding, phospholipase c, phosphoinositide-specific
• 由来する生物種: Rattus norvegicus (Norway rat)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 141267.12

構造登録者

Essen, L.-O.,Perisic, O.,Williams, R.L. (登録日: 1997-03-31, 公開日: 1997-07-07, 最終更新日: 2024-02-21)

主引用文献

Essen, L.O.,Perisic, O.,Cheung, R.,Katan, M.,Williams, R.L.
Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta.
Nature, 380:595-602, 1996

PubMed Abstract: Mammalian phosphoinositide-specific phospholipase C enzymes (PI-PLC) act as signal transducers that generate two second messengers, inositol-1,4,5-trisphosphate and diacylglycerol. The 2.4-A structure of phospholipase C delta 1 reveals a multidomain protein incorporating modules shared by many signalling proteins. The structure suggests a mechanism for membrane attachment and Ca2+-dependent hydrolysis of second-messenger precursors. The regulation and reversible membrane association of PI-PLC may serve as a model for understanding other multidomain enzymes involved in phospholipid signalling.

PubMed: 8602259
DOI: 10.1038/380595a0

実験手法

X-RAY DIFFRACTION (2.5 Å)