2IPK

Crystal Structure of the MHC Class II Molecule HLA-DR1 in Complex with the Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine) and the Superantigen, SEC3 Variant 3B2

2IPK の概要

• エントリーDOI: 10.2210/pdb2ipk/pdb
• 関連するPDBエントリー: 1DLH 1JWU
• 分子名称: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, HA related Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine), ... (5 entities in total)
• 機能のキーワード: hla, dr1, mhc, major histocompatibility complex, fluorogenic probe, sec3, 4-(n, n-dimethylamino)phthalimidoalanyl, dapa, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P01903 P04229; Secreted: P0A0L3
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 72848.96

構造登録者

Nguyen, T.T.,Stern, L.J. (登録日: 2006-10-12, 公開日: 2007-03-13, 最終更新日: 2023-08-30)

• 主引用文献: Venkatraman, P.,Nguyen, T.T.,Sainlos, M.,Bilsel, O.,Chitta, S.,Imperiali, B.,Stern, L.J.; Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells.; Nat.Chem.Biol., 3:222-228, 2007; PubMed: 17351628; DOI: 10.1038/nchembio868

実験手法

X-RAY DIFFRACTION (2.3 Å)