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2IPJ

Crystal structure of h3alpha-hydroxysteroid dehydrogenase type 3 mutant Y24A in complex with NADP+ and epi-testosterone

Summary for 2IPJ
Entry DOI10.2210/pdb2ipj/pdb
Related2IPF 2IPG
DescriptorAldo-keto reductase family 1 member C2, SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
Functional Keywords3a-hsd, akr1c21, akr, aldo-keto reductase, hsd, hydroxysteroid dehydrogenase, open conformation, epi-testosterone, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : P52895
Total number of polymer chains2
Total formula weight75916.50
Authors
Faucher, F.,Cantin, L.,Pereira de Jesus-Tran, K.,Luu-the, V.,Labrie, F.,Breton, R. (deposition date: 2006-10-12, release date: 2007-06-19, Last modification date: 2023-08-30)
Primary citationFaucher, F.,Cantin, L.,Pereira de Jesus-Tran, K.,Lemieux, M.,Luu-The, V.,Labrie, F.,Breton, R.
Mouse 17alpha-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding.
J.Mol.Biol., 369:525-540, 2007
Cited by
PubMed: 17442338
DOI: 10.1016/j.jmb.2007.03.058
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

217705

數據於2024-03-27公開中

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