2IPJ
Crystal structure of h3alpha-hydroxysteroid dehydrogenase type 3 mutant Y24A in complex with NADP+ and epi-testosterone
Summary for 2IPJ
Entry DOI | 10.2210/pdb2ipj/pdb |
Related | 2IPF 2IPG |
Descriptor | Aldo-keto reductase family 1 member C2, SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total) |
Functional Keywords | 3a-hsd, akr1c21, akr, aldo-keto reductase, hsd, hydroxysteroid dehydrogenase, open conformation, epi-testosterone, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P52895 |
Total number of polymer chains | 2 |
Total formula weight | 75916.50 |
Authors | Faucher, F.,Cantin, L.,Pereira de Jesus-Tran, K.,Luu-the, V.,Labrie, F.,Breton, R. (deposition date: 2006-10-12, release date: 2007-06-19, Last modification date: 2023-08-30) |
Primary citation | Faucher, F.,Cantin, L.,Pereira de Jesus-Tran, K.,Lemieux, M.,Luu-The, V.,Labrie, F.,Breton, R. Mouse 17alpha-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding. J.Mol.Biol., 369:525-540, 2007 Cited by PubMed: 17442338DOI: 10.1016/j.jmb.2007.03.058 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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