2IPJ

Crystal structure of h3alpha-hydroxysteroid dehydrogenase type 3 mutant Y24A in complex with NADP+ and epi-testosterone

2IPJ の概要

関連するPDBエントリー2IPG 2IPF
分子名称Aldo-keto reductase family 1 member C2, SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
機能のキーワード3a-hsd, akr1c21, akr, aldo-keto reductase, hsd, hydroxysteroid dehydrogenase, open conformation, epi-testosterone, oxidoreductase
由来する生物種Homo sapiens (human)
細胞内の位置Cytoplasm  P52895
ポリマー鎖数2
分子量合計75916.5
構造登録者
Faucher, F.,Cantin, L.,Pereira de Jesus-Tran, K.,Luu-the, V.,Labrie, F.,Breton, R. (登録日: 2006-10-12, 公開日: 2007-06-19, 最終更新日: 2018-01-24)
主引用文献
Faucher, F.,Cantin, L.,Pereira de Jesus-Tran, K.,Lemieux, M.,Luu-The, V.,Labrie, F.,Breton, R.
Mouse 17alpha-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding.
J.Mol.Biol., 369:525-540, 2007
PubMed: 17442338 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.jmb.2007.03.058
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.8 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2261000.7%4.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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