Crystal structure of 17alpha-hydroxysteroid dehydrogenase mutant K31A in complex with NADP+ and epi-testosterone

Summary for 2IPG

Related2IPJ 2IPF
Descriptor3(17)alpha-hydroxysteroid dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE, ... (6 entities in total)
Functional Keywords17a-hsd, akr1c21, akr, aldo-keto reductase, hsd, hydroxysteroid dehydrogenase, open conformation, epi-testosterone, oxidoreductase
Biological sourceMus musculus (Mouse)
Total number of polymer chains2
Total molecular weight75372.25
Faucher, F.,Cantin, L.,Pereira de Jesus-Tran, K.,Lemieux, M.,Luu-the, V.,Labrie, F.,Breton, R. (deposition date: 2006-10-12, release date: 2007-06-19, Last modification date: 2019-02-06)
Primary citation
Faucher, F.,Cantin, L.,Pereira de Jesus-Tran, K.,Lemieux, M.,Luu-The, V.,Labrie, F.,Breton, R.
Mouse 17alpha-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding.
J.Mol.Biol., 369:525-540, 2007
PubMed: 17442338 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2007.03.058
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21670 1.8% 1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution