2INQ

Neutron Crystal Structure of Escherichia coli Dihydrofolate Reductase Bound to the Anti-cancer drug, Methotrexate

2INQ の概要

• エントリーDOI: 10.2210/pdb2inq/pdb
• 分子名称: Dihydrofolate reductase, N-(4-{[(2,4-DIAMINOPTERIDIN-1-IUM-6-YL)METHYL](METHYL)AMINO}BENZOYL)-L-GLUTAMIC ACID (3 entities in total)
• 機能のキーワード: neutron structure; deuterium exchange; pseudo-rossman fold; nucleotide binding domain; chemotherapy, oxidoreductase
• 由来する生物種: Escherichia coli K12
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36951.55

構造登録者

Bennett, B.C.,Langan, P.A.,Coates, L.,Schoenborn, B.,Dealwis, C.G. (登録日: 2006-10-08, 公開日: 2007-02-06, 最終更新日: 2023-08-30)

• 主引用文献: Bennett, B.C.,Langan, P.A.,Coates, L.,Mustyakimov, M.,Schoenborn, B.,Howell, E.E.,Dealwis, C.G.; Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate.; Proc.Natl.Acad.Sci.Usa, 103:18493-18498, 2006; PubMed: 17130456; DOI: 10.1073/pnas.0604977103

実験手法

NEUTRON DIFFRACTION (2.2 Å)