2ING
X-ray Structure of the BRCA1 BRCT mutant M1775K
Summary for 2ING
Entry DOI | 10.2210/pdb2ing/pdb |
Descriptor | Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION (3 entities in total) |
Functional Keywords | zinc-finger, dna-binding, dna repair, disease mutation, phosphorylation, dna binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus . Isoform 3: Cytoplasm. Isoform 5: Cytoplasm : P38398 |
Total number of polymer chains | 1 |
Total formula weight | 24592.03 |
Authors | Birrane, G.,Soni, A.,Ladias, J.A.A. (deposition date: 2006-10-07, release date: 2007-09-04, Last modification date: 2023-08-30) |
Primary citation | Tischkowitz, M.,Hamel, N.,Carvalho, M.A.,Birrane, G.,Soni, A.,van Beers, E.H.,Joosse, S.A.,Wong, N.,Novak, D.,Quenneville, L.A.,Grist, S.A.,Nederlof, P.M.,Goldgar, D.E.,Tavtigian, S.V.,Monteiro, A.N.,Ladias, J.A.,Foulkes, W.D. Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach. Eur.J.Hum.Genet., 16:820-832, 2008 Cited by PubMed: 18285836DOI: 10.1038/ejhg.2008.13 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6 Å) |
Structure validation
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