2IL2
Crystal Structure of Human Renin Complexed with Inhibitor
Summary for 2IL2
Entry DOI | 10.2210/pdb2il2/pdb |
Related | 2IKO 2IKU |
Descriptor | Renin, N-[2-({2-AMINO-6-ETHYL-5-[4-(3-METHOXYPROPYL)-2,2-DIMETHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-YL]PYRIMIDIN-4-YL}AMINO)ETHYL]NAPHTHALENE-2-SULFONAMIDE, CITRIC ACID, ... (4 entities in total) |
Functional Keywords | renin, inhibitors, drug design, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P00797 |
Total number of polymer chains | 2 |
Total formula weight | 75963.63 |
Authors | Mochalkin, I. (deposition date: 2006-10-02, release date: 2006-12-05, Last modification date: 2023-08-30) |
Primary citation | Sarver, R.W.,Peevers, J.,Cody, W.L.,Ciske, F.L.,Dyer, J.,Emerson, S.D.,Hagadorn, J.C.,Holsworth, D.D.,Jalaie, M.,Kaufman, M.,Mastronardi, M.,McConnell, P.,Powell, N.A.,Quin, J.,Van Huis, C.A.,Zhang, E.,Mochalkin, I. Binding thermodynamics of substituted diaminopyrimidine renin inhibitors. Anal.Biochem., 360:30-40, 2007 Cited by PubMed: 17113558DOI: 10.1016/j.ab.2006.10.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.24 Å) |
Structure validation
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