2IEI
Crystal structure of rabbit muscle glycogen phosphorylase in complex with 3,4-dihydro-2-quinolone
Summary for 2IEI
Entry DOI | 10.2210/pdb2iei/pdb |
Related | 2IEG |
Descriptor | Glycogen phosphorylase, muscle form, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, (S)-2-CHLORO-N-(1-(2-(2-HYDROXYETHYLAMINO)-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL)-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE, ... (4 entities in total) |
Functional Keywords | glycogen phosphorylase, diabetes, glucose, transferase |
Biological source | Oryctolagus cuniculus (rabbit) |
Total number of polymer chains | 2 |
Total formula weight | 195942.54 |
Authors | Birch, A.M.,Kenny, P.W.,Oikonomakos, N.G.,Otterbein, L.,Schofield, P.,Whittamore, P.R.O.,Whalley, D.P.,Rowsell, S.,Pauptit, R.,Pannifer, A.,Breed, J.,Minshull, C. (deposition date: 2006-09-19, release date: 2006-12-26, Last modification date: 2011-07-13) |
Primary citation | Birch, A.M.,Kenny, P.W.,Oikonomakos, N.G.,Otterbein, L.,Schofield, P.,Whittamore, P.R.,Whalley, D.P. Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors. Bioorg.Med.Chem.Lett., 17:394-399, 2007 Cited by PubMed: 17095214DOI: 10.1016/j.bmcl.2006.10.037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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