2IEI

Crystal structure of rabbit muscle glycogen phosphorylase in complex with 3,4-dihydro-2-quinolone

2IEI の概要

• エントリーDOI: 10.2210/pdb2iei/pdb
• 関連するPDBエントリー: 2IEG
• 分子名称: Glycogen phosphorylase, muscle form, (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, (S)-2-CHLORO-N-(1-(2-(2-HYDROXYETHYLAMINO)-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL)-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE, ... (4 entities in total)
• 機能のキーワード: glycogen phosphorylase, diabetes, glucose, transferase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 195942.54

構造登録者

Birch, A.M.,Kenny, P.W.,Oikonomakos, N.G.,Otterbein, L.,Schofield, P.,Whittamore, P.R.O.,Whalley, D.P.,Rowsell, S.,Pauptit, R.,Pannifer, A.,Breed, J.,Minshull, C. (登録日: 2006-09-19, 公開日: 2006-12-26, 最終更新日: 2011-07-13)

• 主引用文献: Birch, A.M.,Kenny, P.W.,Oikonomakos, N.G.,Otterbein, L.,Schofield, P.,Whittamore, P.R.,Whalley, D.P.; Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors.; Bioorg.Med.Chem.Lett., 17:394-399, 2007; PubMed: 17095214; DOI: 10.1016/j.bmcl.2006.10.037

実験手法

X-RAY DIFFRACTION (1.91 Å)