2IEH
Crystal structure of human kinesin Eg5 in complex with (R)-mon97, a new monastrol-based inhibitor that binds as (R)-enantiomer
Summary for 2IEH
Entry DOI | 10.2210/pdb2ieh/pdb |
Descriptor | Kinesin-like protein KIF11, MAGNESIUM ION, POTASSIUM ION, ... (8 entities in total) |
Functional Keywords | beta-sheet core, flanked by three alpha-helices on each side, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P52732 |
Total number of polymer chains | 2 |
Total formula weight | 83697.41 |
Authors | Garcia-Saez, I.,Kozielski, F. (deposition date: 2006-09-19, release date: 2007-01-23, Last modification date: 2023-08-30) |
Primary citation | Garcia-Saez, I.,DeBonis, S.,Lopez, R.,Trucco, F.,Rousseau, B.,Thuery, P.,Kozielski, F. Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration. J.Biol.Chem., 282:9740-9747, 2007 Cited by PubMed: 17251189DOI: 10.1074/jbc.M608883200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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