2IDC

Structure of the Histone H3-Asf1 Chaperone Interaction

2IDC の概要

• エントリーDOI: 10.2210/pdb2idc/pdb
• 関連するPDBエントリー: 1ROC
• 分子名称: ANTI-SILENCING PROTEIN 1 AND HISTONE H3 CHIMERA (2 entities in total)
• 機能のキーワード: ig-like fold, asf1, h3, histone, chaperone, chromatin, replication-chaperone complex, replication/chaperone
• 由来する生物種: Saccharomyces cerevisiae (Baker's yeast); 詳細
• 細胞内の位置: Nucleus: P61830
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20084.73

構造登録者

Antczak, A.J.,Tsubota, T.,Kaufman, P.D.,Berger, J.M. (登録日: 2006-09-14, 公開日: 2007-01-30, 最終更新日: 2023-08-30)

主引用文献

Antczak, A.J.,Tsubota, T.,Kaufman, P.D.,Berger, J.M.
Structure of the yeast histone H3-ASF1 interaction: implications for chaperone mechanism, species-specific interactions, and epigenetics.
Bmc Struct.Biol., 6:26-26, 2006

PubMed Abstract: The histone H3/H4 chaperone Asf1 (anti-silencing function 1) is required for the establishment and maintenance of proper chromatin structure, as well as for genome stability in eukaryotes. Asf1 participates in both DNA replication-coupled (RC) and replication-independent (RI) histone deposition reactions in vitro and interacts with complexes responsible for both pathways in vivo. Asf1 is known to directly bind histone H3, however, high-resolution structural information about the geometry of this interaction was previously unknown.

PubMed: 17166288
DOI: 10.1186/1472-6807-6-26

実験手法

X-RAY DIFFRACTION (2.2 Å)