2ID4

The 1.9 A structure of Kex2 in complex with an Ac-R-E-R-K-chloromethyl ketone inhibitor.

2ID4 の概要

• エントリーDOI: 10.2210/pdb2id4/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000246
• 分子名称: Kexin, Ac-RERK-CMK inhibitor, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: kex2, kexin, furin, proprotein, prohormone, convertase, subtilisin like protease, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast); 詳細
• 細胞内の位置: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein: P13134
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 113263.51

構造登録者

Wheatley, J.L.,Holyoak, T. (登録日: 2006-09-14, 公開日: 2007-05-01, 最終更新日: 2023-11-15)

• 主引用文献: Wheatley, J.L.,Holyoak, T.; Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2.; Proc.Natl.Acad.Sci.Usa, 104:6626-6631, 2007; PubMed: 17426142; DOI: 10.1073/pnas.0701983104

実験手法