2ICW

Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule

2ICW の概要

• エントリーDOI: 10.2210/pdb2icw/pdb
• 分子名称: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, haemagglutinin peptide, ... (7 entities in total)
• 機能のキーワード: tcr, mhc, superantigen, protein-protein complex, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P01903 P04229
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 188401.76

構造登録者

Wang, L.,Zhao, Y.,Li, H. (登録日: 2006-09-13, 公開日: 2007-03-20, 最終更新日: 2024-11-13)

主引用文献

Wang, L.,Zhao, Y.,Li, Z.,Guo, Y.,Jones, L.L.,Kranz, D.M.,Mourad, W.,Li, H.
Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC.
Nat.Struct.Mol.Biol., 14:169-171, 2007

PubMed Abstract: 'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.

PubMed: 17220897
DOI: 10.1038/nsmb1193

実験手法

X-RAY DIFFRACTION (2.41 Å)