2IAN
Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR
Summary for 2IAN
Entry DOI | 10.2210/pdb2ian/pdb |
Related | 1KLG 1KLU 2IAL 2IAM |
Descriptor | HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, 15-mer peptide from Triosephosphate isomerase, ... (6 entities in total) |
Functional Keywords | major histocompatibility complex, t cell receptor, t cell stimulation, melanoma, tumor antigen, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein: P01903 P04229 Membrane; Single-pass membrane protein (Potential): P01848 P01850 |
Total number of polymer chains | 20 |
Total formula weight | 376776.42 |
Authors | Deng, L.,Langley, R.J.,Mariuzza, R.A. (deposition date: 2006-09-08, release date: 2007-04-03, Last modification date: 2023-10-25) |
Primary citation | Deng, L.,Langley, R.J.,Brown, P.H.,Xu, G.,Teng, L.,Wang, Q.,Gonzales, M.I.,Callender, G.G.,Nishimura, M.I.,Topalian, S.L.,Mariuzza, R.A. Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor Nat.Immunol., 8:398-408, 2007 Cited by PubMed: 17334368DOI: 10.1038/ni1447 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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