2IAE

Crystal structure of a protein phosphatase 2A (PP2A) holoenzyme.

Summary for 2IAE

• Entry DOI: 10.2210/pdb2iae/pdb
• Related: 1B3U
• Related PRD ID: PRD_000212
• Descriptor: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ... (5 entities in total)
• Functional Keywords: protein phosphorylation, phosphatase, pp2a, b56, tumor suppressor, methylation, hydrolase, toxin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Mus musculus (house mouse); More
• Cellular location: Cytoplasm : Q76MZ3 P67775; Nucleus: Q13362
• Total number of polymer chains: 8
• Total formula weight: 300705.13

Authors

Cho, U.S.,Xu, W. (deposition date: 2006-09-07, release date: 2006-12-26, Last modification date: 2023-11-15)

• Primary citation: Cho, U.S.,Xu, W.; Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme.; Nature, 445:53-57, 2007; PubMed: 17086192; DOI: 10.1038/nature05351

Experimental method

X-RAY DIFFRACTION (3.5 Å)