2I7N

Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA

Summary for 2I7N

• Entry DOI: 10.2210/pdb2i7n/pdb
• Related: 2I7P
• Descriptor: Pantothenate kinase 1, ACETYL COENZYME *A (3 entities in total)
• Functional Keywords: pank, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q8TE04
• Total number of polymer chains: 2
• Total formula weight: 81971.52

Authors

Hong, B.S.,Wang, L.,Tempel, W.,Loppnau, P.,Allali-Hassani, A.,Arrowsmith, C.H.,Edwards, A.M.,Sundstrom, M.,Weigelt, J.,Bochkarev, A.,Park, H.W. (deposition date: 2006-08-31, release date: 2006-12-26, Last modification date: 2024-02-21)

• Primary citation: Hong, B.S.,Senisterra, G.,Rabeh, W.M.,Vedadi, M.,Leonardi, R.,Zhang, Y.M.,Rock, C.O.,Jackowski, S.,Park, H.W.; Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.; J.Biol.Chem., 282:27984-27993, 2007; PubMed: 17631502; DOI: 10.1074/jbc.M701915200

Experimental method

X-RAY DIFFRACTION (1.9 Å)