2I5C

Crystal structure of the C-terminal PH domain of pleckstrin in complex with D-myo-Ins(1,2,3,4,5)P5

2I5C の概要

• エントリーDOI: 10.2210/pdb2i5c/pdb
• 関連するPDBエントリー: 1ZM0
• 分子名称: Pleckstrin, (1R,2S,3R,4S,5S,6R)-6-HYDROXYCYCLOHEXANE-1,2,3,4,5-PENTAYL PENTAKIS[DIHYDROGEN (PHOSPHATE)] (3 entities in total)
• 機能のキーワード: ph domain, protein-inositol phosphate complex, lipid binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 39093.66

構造登録者

Jackson, S.G.,Haslam, R.J.,Junop, M.S. (登録日: 2006-08-24, 公開日: 2007-08-07, 最終更新日: 2024-02-21)

主引用文献

Jackson, S.G.,Zhang, Y.,Haslam, R.J.,Junop, M.S.
Structural analysis of the carboxy terminal PH domain of pleckstrin bound to D-myo-inositol 1,2,3,5,6-pentakisphosphate.
Bmc Struct.Biol., 7:80-80, 2007

PubMed Abstract: Pleckstrin homology (PH) domains are one of the most prevalent domains in the human proteome and represent the major phosphoinositide-binding module. These domains are often found in signaling proteins and function predominately by targeting their host proteins to the cell membrane. Inositol phosphates, which are structurally similar to phosphoinositides, are not only known to play a role as signaling molecules but are also capable of being bound by PH domains.

PubMed: 18034889
DOI: 10.1186/1472-6807-7-80

実験手法

X-RAY DIFFRACTION (1.75 Å)