2I39

Crystal structure of Vaccinia virus N1L protein

2I39 の概要

• エントリーDOI: 10.2210/pdb2i39/pdb
• 分子名称: Protein N1, (4S)-2-METHYL-2,4-PENTANEDIOL (3 entities in total)
• 機能のキーワード: all alpha, viral protein
• 由来する生物種: Vaccinia virus
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 97132.80

構造登録者

Aoyagi, M.,Aleshin, A.E.,Stec, B.,Liddington, R.C. (登録日: 2006-08-17, 公開日: 2006-11-21, 最終更新日: 2024-02-21)

主引用文献

Aoyagi, M.,Zhai, D.,Jin, C.,Aleshin, A.E.,Stec, B.,Reed, J.C.,Liddington, R.C.
Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein.
Protein Sci., 16:118-124, 2007

PubMed Abstract: Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks detectable Bcl-2 homology (BH) motifs at the sequence level, we show that N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2 family proteins in vitro, consistent with a role for N1L in modulating host antiviral defenses.

PubMed: 17123957
DOI: 10.1110/ps.062454707

実験手法

X-RAY DIFFRACTION (2.2 Å)