2I1P

Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin

2I1P の概要

• エントリーDOI: 10.2210/pdb2i1p/pdb
• NMR情報: BMRB: 7263
• 分子名称: Low-density lipoprotein receptor-related protein 2, CALCIUM ION (2 entities in total)
• 機能のキーワード: low density lipoprotein receptor, cysteine-rich repeat, ligand binding domain, calcium cage, ligand binding protein
• 由来する生物種: Rattus norvegicus (Norway rat)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 5137.70

構造登録者

Wolf, C.A.,Dancea, F.,Shi, M.,Bade-Noskova, V.,Rueterjans, H.,Kerjaschki, D.,Luecke, C. (登録日: 2006-08-14, 公開日: 2007-02-13, 最終更新日: 2024-11-13)

主引用文献

Wolf, C.A.,Dancea, F.,Shi, M.,Bade-Noskova, V.,Rueterjans, H.,Kerjaschki, D.,Luecke, C.
Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin.
J.Biomol.Nmr, 37:321-328, 2007

PubMed Abstract: Megalin, an approx. 600 kDa transmembrane glycoprotein that acts as multi-ligand transporter, is a member of the low density lipoprotein receptor gene family. Several cysteine-rich repeats, each consisting of about 40 residues, are responsible for the multispecific binding of ligands. The solution structure of the twelfth cysteine-rich ligand-binding repeat with class A motif found in megalin features two short beta-strands and two helical turns, yielding the typical fold with a I-III, II-V and IV-VI disulfide bridge connectivity pattern and a calcium coordination site at the C-terminal end. The resulting differences in electrostatic surface potential compared to other ligand-binding modules of this gene family, however, may be responsible for the functional divergence.

PubMed: 17245526
DOI: 10.1007/s10858-006-9129-3

実験手法

SOLUTION NMR