2I1M
cFMS tyrosine kinase (tie2 KID) in complex with an arylamide inhibitor
Summary for 2I1M
Entry DOI | 10.2210/pdb2i1m/pdb |
Related | 2I0V 2I0Y |
Descriptor | Macrophage colony-stimulating factor 1 receptor, 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE (3 entities in total) |
Functional Keywords | kinase domain, kinase inhibitor complex, transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein: P07333 |
Total number of polymer chains | 1 |
Total formula weight | 37952.45 |
Authors | Schubert, C.,Schalk-Hihi, C. (deposition date: 2006-08-14, release date: 2006-11-28, Last modification date: 2024-02-21) |
Primary citation | Schubert, C.,Schalk-Hihi, C.,Struble, G.T.,Ma, H.C.,Petrounia, I.P.,Brandt, B.,Deckman, I.C.,Patch, R.J.,Player, M.R.,Spurlino, J.C.,Springer, B.A. Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors. J.Biol.Chem., 282:4094-4101, 2007 Cited by PubMed: 17132624DOI: 10.1074/jbc.M608183200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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